Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain

The imprinted Kcnq1 domain contains a differentially methylated region (KvDMR) in intron 11 of Kcnq1. The Kcnq1ot1 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resulting in cis-repression of neighboring genes. The KvDMR encompasses the Kcnq1ot1 promoter, CTCF s...

Descripción completa

Detalles Bibliográficos
Autores principales: Schultz, Bryant M., Gallicio, Gwendolyn A., Cesaroni, Matteo, Lupey, Lena N., Engel, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333379/
https://www.ncbi.nlm.nih.gov/pubmed/25539921
http://dx.doi.org/10.1093/nar/gku1324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333379/
https://www.ncbi.nlm.nih.gov/pubmed/25539921
http://dx.doi.org/10.1093/nar/gku1324

Ejemplares similares