CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells

Controllable gene delivery via vector-based systems remains a formidable challenge in mammalian synthetic biology and a desirable asset in gene therapy applications. Here, we introduce a methodology to control the copies and residence time of a gene product delivered in host human cells but also sel...

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Detalles Bibliográficos
Autores principales: Moore, Richard, Spinhirne, Alec, Lai, Michael J., Preisser, Samantha, Li, Yi, Kang, Taek, Bleris, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333380/
https://www.ncbi.nlm.nih.gov/pubmed/25527740
http://dx.doi.org/10.1093/nar/gku1326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333380/
https://www.ncbi.nlm.nih.gov/pubmed/25527740
http://dx.doi.org/10.1093/nar/gku1326

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