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CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells
Controllable gene delivery via vector-based systems remains a formidable challenge in mammalian synthetic biology and a desirable asset in gene therapy applications. Here, we introduce a methodology to control the copies and residence time of a gene product delivered in host human cells but also sel...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333380/ https://www.ncbi.nlm.nih.gov/pubmed/25527740 http://dx.doi.org/10.1093/nar/gku1326 |