Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme

The native structure of the Azoarcus group I ribozyme is stabilized by the cooperative formation of tertiary interactions between double helical domains. Thus, even single mutations that break this network of tertiary interactions reduce ribozyme activity in physiological Mg(2+) concentrations. Here...

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Detalles Bibliográficos
Autores principales: Lee, Hui-Ting, Kilburn, Duncan, Behrouzi, Reza, Briber, Robert M., Woodson, Sarah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333387/
https://www.ncbi.nlm.nih.gov/pubmed/25541198
http://dx.doi.org/10.1093/nar/gku1335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333387/
https://www.ncbi.nlm.nih.gov/pubmed/25541198
http://dx.doi.org/10.1093/nar/gku1335

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