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Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme
The native structure of the Azoarcus group I ribozyme is stabilized by the cooperative formation of tertiary interactions between double helical domains. Thus, even single mutations that break this network of tertiary interactions reduce ribozyme activity in physiological Mg(2+) concentrations. Here...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333387/ https://www.ncbi.nlm.nih.gov/pubmed/25541198 http://dx.doi.org/10.1093/nar/gku1335 |