Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Anti-microRNA (miRNA) oligonucleotides (AMOs) with 2′-O-Methyl (2′OMe) residues are commonly used to study miRNA function and can achieve high potency, with low cytotoxicity. Not withstanding this, we demonstrate the sequence-dependent capacity of 2′OMe AMOs to inhibit Toll-like receptor (TLR) 7 and...

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Detalles Bibliográficos
Autores principales: Sarvestani, Soroush T., Stunden, H. James, Behlke, Mark A., Forster, Samuel C., McCoy, Claire E., Tate, Michelle D., Ferrand, Jonathan, Lennox, Kim A., Latz, Eicke, Williams, Bryan R.G., Gantier, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333393/
https://www.ncbi.nlm.nih.gov/pubmed/25539920
http://dx.doi.org/10.1093/nar/gku1343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333393/
https://www.ncbi.nlm.nih.gov/pubmed/25539920
http://dx.doi.org/10.1093/nar/gku1343

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