Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibiotics. We report biophysical and kinetic studies on the São Paulo MBL (SPM-1), which reveal its Zn(ii) ion usage and mechanism as characteristic of the clinically important di-Zn(ii) dependent B1 MBL subfamily. Biophysi...

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Detalles Bibliográficos
Autores principales: Brem, Jürgen, Struwe, Weston B., Rydzik, Anna M., Tarhonskaya, Hanna, Pfeffer, Inga, Flashman, Emily, van Berkel, Sander S., Spencer, James, Claridge, Timothy D. W., McDonough, Michael A., Benesch, Justin L. P., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333608/
https://www.ncbi.nlm.nih.gov/pubmed/25717359
http://dx.doi.org/10.1039/c4sc01752h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333608/
https://www.ncbi.nlm.nih.gov/pubmed/25717359
http://dx.doi.org/10.1039/c4sc01752h

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