Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity

[Image: see text] The cyclin groove is an important recognition site for substrates of the cell cycle cyclin dependent kinases and provides an opportunity for highly selective inhibition of kinase activity through a non-ATP competitive mechanism. The key peptide residues of the cyclin binding motif...

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Detalles Bibliográficos
Autores principales: Premnath, Padmavathy Nandha, Craig, Sandra N., Liu, Shu, Anderson, Erin L., Grigoroudis, Asterios I., Kontopidis, George, Perkins, Tracy L., Wyatt, Michael D., Pittman, Douglas L., McInnes, Campbell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334226/
https://www.ncbi.nlm.nih.gov/pubmed/25454794
http://dx.doi.org/10.1021/jm5015023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334226/
https://www.ncbi.nlm.nih.gov/pubmed/25454794
http://dx.doi.org/10.1021/jm5015023

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