Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

[Image: see text] Bryostatin 1 is in clinical trials for the treatment of cancer and Alzheimer’s disease and is a candidate for a first-in-class approach to HIV/AIDS eradication. It is neither readily available nor optimally suited for clinical use. Using a function oriented synthesis strategy, a ne...

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Detalles Bibliográficos
Autores principales: Wender, Paul A., Nakagawa, Yu, Near, Katherine E., Staveness, Daryl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334246/
https://www.ncbi.nlm.nih.gov/pubmed/25238583
http://dx.doi.org/10.1021/ol502491f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334246/
https://www.ncbi.nlm.nih.gov/pubmed/25238583
http://dx.doi.org/10.1021/ol502491f

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