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Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
BACKGROUND: This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model. METHODS: We used behavioral analysis, mass spectrometry, metabolomics, electron microscopy, and western analysis to test the hypothesis that...
Autores principales: | Naviaux, Jane C, Wang, Lin, Li, Kefeng, Bright, A Taylor, Alaynick, William A, Williams, Kenneth R, Powell, Susan B, Naviaux, Robert K |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334917/ https://www.ncbi.nlm.nih.gov/pubmed/25705365 http://dx.doi.org/10.1186/2040-2392-6-1 |
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