What can we learn from molecular dynamics simulations for GPCR drug design?

Recent years have seen a tremendous progress in the elucidation of experimental structural information for G-protein coupled receptors (GPCRs). Although for the vast majority of pharmaceutically relevant GPCRs structural information is still accessible only by homology models the steadily increasing...

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Detalles Bibliográficos
Autores principales: Tautermann, Christofer S., Seeliger, Daniel, Kriegl, Jan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334948/
https://www.ncbi.nlm.nih.gov/pubmed/25709761
http://dx.doi.org/10.1016/j.csbj.2014.12.002

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