Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endoplasmic reticulum (ER) stress and activation of the u...

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Detalles Bibliográficos
Autores principales: Kung, Louise H. W., Rajpar, M. Helen, Preziosi, Richard, Briggs, Michael D., Boot-Handford, Raymond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334961/
https://www.ncbi.nlm.nih.gov/pubmed/25693198
http://dx.doi.org/10.1371/journal.pone.0117016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334961/
https://www.ncbi.nlm.nih.gov/pubmed/25693198
http://dx.doi.org/10.1371/journal.pone.0117016

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