Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endoplasmic reticulum (ER) stress and activation of the u...

Descripción completa

Detalles Bibliográficos
Autores principales: Kung, Louise H. W., Rajpar, M. Helen, Preziosi, Richard, Briggs, Michael D., Boot-Handford, Raymond P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334961/
https://www.ncbi.nlm.nih.gov/pubmed/25693198
http://dx.doi.org/10.1371/journal.pone.0117016

Ejemplares similares

Ejemplares similares