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A computational design approach for virtual screening of peptide interactions across K(+) channel families()

Ion channels represent a large family of membrane proteins with many being well established targets in pharmacotherapy. The ‘druggability’ of heteromeric channels comprised of different subunits remains obscure, due largely to a lack of channel-specific probes necessary to delineate their therapeuti...

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Detalles Bibliográficos
Autores principales: Doupnik, Craig A., Parra, Katherine C., Guida, Wayne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334993/
https://www.ncbi.nlm.nih.gov/pubmed/25709757
http://dx.doi.org/10.1016/j.csbj.2014.11.004