Comparison of Effects of p53 Null and Gain-of-Function Mutations on Salivary Tumors in MMTV-Hras Transgenic Mice

p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions. To investigate these gain-of-function effects in vivo, we generated mice of three different genotypes: MMTV...

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Detalles Bibliográficos
Autores principales: Jiang, Dadi, Dumur, Catherine I., Massey, H. Davis, Ramakrishnan, Viswanathan, Subler, Mark A., Windle, Jolene J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335025/
https://www.ncbi.nlm.nih.gov/pubmed/25695772
http://dx.doi.org/10.1371/journal.pone.0118029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335025/
https://www.ncbi.nlm.nih.gov/pubmed/25695772
http://dx.doi.org/10.1371/journal.pone.0118029

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