Guanine-Modified Inhibitory Oligonucleotides Efficiently Impair TLR7- and TLR9-Mediated Immune Responses of Human Immune Cells

Activation of TLR7 and TLR9 by endogenous RNA- or DNA-containing ligands, respectively, is thought to contribute to the complicated pathophysiology of systemic lupus erythematosus (SLE). These ligands induce the release of type-I interferons by plasmacytoid dendritic cells and autoreactive antibodie...

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Detalles Bibliográficos
Autores principales: Römmler, Franziska, Hammel, Monika, Waldhuber, Anna, Müller, Tina, Jurk, Marion, Uhlmann, Eugen, Wagner, Hermann, Vollmer, Jörg, Miethke, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335036/
https://www.ncbi.nlm.nih.gov/pubmed/25695778
http://dx.doi.org/10.1371/journal.pone.0116703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335036/
https://www.ncbi.nlm.nih.gov/pubmed/25695778
http://dx.doi.org/10.1371/journal.pone.0116703

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