Transcriptomic analysis and 3D bioengineering of astrocytes indicate ROCK inhibition produces cytotrophic astrogliosis

Astrocytes provide trophic, structural and metabolic support to neurons, and are considered genuine targets in regenerative neurobiology, as their phenotype arbitrates brain integrity during injury. Inhibitors of Rho kinase (ROCK) cause stellation of cultured 2D astrocytes, increased L-glutamate tra...

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Detalles Bibliográficos
Autores principales: O'Shea, Ross D., Lau, Chew L., Zulaziz, Natasha, Maclean, Francesca L., Nisbet, David R., Horne, Malcolm K., Beart, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335181/
https://www.ncbi.nlm.nih.gov/pubmed/25750613
http://dx.doi.org/10.3389/fnins.2015.00050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335181/
https://www.ncbi.nlm.nih.gov/pubmed/25750613
http://dx.doi.org/10.3389/fnins.2015.00050

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