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A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages

The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental and inflammatory stimulus-inducible genes in macrophages, but the mechanisms underlying these two different functions are largely unknown. One possibility is that these different roles are linked to the a...

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Detalles Bibliográficos
Autores principales: Mancino, Alessandra, Termanini, Alberto, Barozzi, Iros, Ghisletti, Serena, Ostuni, Renato, Prosperini, Elena, Ozato, Keiko, Natoli, Gioacchino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335295/
https://www.ncbi.nlm.nih.gov/pubmed/25637355
http://dx.doi.org/10.1101/gad.257592.114