Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing

BACKGROUND: The evolution of mutations in the BCR-ABL1 fusion gene transcript renders CML patients resistant to tyrosine kinase inhibitor (TKI) based therapy. Thus screening for BCR-ABL1 mutations is recommended particularly in patients experiencing poor response to treatment. Herein we describe a n...

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Detalles Bibliográficos
Autores principales: Cavelier, Lucia, Ameur, Adam, Häggqvist, Susana, Höijer, Ida, Cahill, Nicola, Olsson-Strömberg, Ulla, Hermanson, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335374/
https://www.ncbi.nlm.nih.gov/pubmed/25880391
http://dx.doi.org/10.1186/s12885-015-1046-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335374/
https://www.ncbi.nlm.nih.gov/pubmed/25880391
http://dx.doi.org/10.1186/s12885-015-1046-y

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