Cargando…

Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell donors and GMP-compliant manufacturing of antiviral T cells

BACKGROUND: The adoptive transfer of allogeneic antiviral T lymphocytes derived from seropositive donors can safely and effectively reduce or prevent the clinical manifestation of viral infections or reactivations in immunocompromised recipients after hematopoietic stem cell (HSCT) or solid organ tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tischer, Sabine, Priesner, Christoph, Heuft, Hans-Gert, Goudeva, Lilia, Mende, Wolfgang, Barthold, Marc, Kloeß, Stephan, Arseniev, Lubomir, Aleksandrova, Krasimira, Maecker-Kolhoff, Britta, Blasczyk, Rainer, Koehl, Ulrike, Eiz-Vesper, Britta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335407/ https://www.ncbi.nlm.nih.gov/pubmed/25510656 http://dx.doi.org/10.1186/s12967-014-0336-5

Ejemplares similares

Comparative Analysis of Clinical-Scale IFN-γ-Positive T-Cell Enrichment Using Partially and Fully Integrated Platforms
por: Priesner, Christoph, et al.
Publicado: (2016)

Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies
por: Tischer, Sabine, et al.
Publicado: (2011)

Antiviral T-Cell Frequencies in a Healthy Population: Reference Values for Evaluating Antiviral Immune Cell Profiles in Immunocompromised Patients
por: Schulze Lammers, Friederike C., et al.
Publicado: (2022)

Adoptive T-cell immunotherapy from third-party donors: characterization of donors and set up of a T-cell donor registry
por: Eiz-Vesper, Britta, et al.
Publicado: (2013)

Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor
por: Bunse, Carola E., et al.
Publicado: (2013)

Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes
por: Bieling, Maren, et al.
Publicado: (2017)

Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease
por: Schultze-Florey, Rebecca E., et al.
Publicado: (2018)

GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD(2) and Releasing Inducible IL-18
por: Glienke, Wolfgang, et al.
Publicado: (2022)

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection
por: Tischer, Sabine, et al.
Publicado: (2016)

Robust Identification of Suitable T-Cell Subsets for Personalized CMV-Specific T-Cell Immunotherapy Using CD45RA and CD62L Microbeads
por: Mangare, Caroline, et al.
Publicado: (2019)

High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?
por: Heinemann, Nele Carolin, et al.
Publicado: (2020)

Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression
por: Bak, Szilvia, et al.
Publicado: (2018)

Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy
por: Schillingmann, Damaris A., et al.
Publicado: (2019)

Secreted β(3)-Integrin Enhances Natural Killer Cell Activity against Acute Myeloid Leukemia Cells
por: Skaik, Younis, et al.
Publicado: (2014)

Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy
por: Laubert, Miriam, et al.
Publicado: (2022)

Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L(+) T Cells for Manufacturing of Gene Therapy Medicinal Products
por: Priesner, Christoph, et al.
Publicado: (2016)

Long-Term Follow-Up after Adoptive Transfer of BK-Virus-Specific T Cells in Hematopoietic Stem Cell Transplant Recipients
por: Koldehoff, Michael, et al.
Publicado: (2023)

Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses
por: Bonifacius, Agnes, et al.
Publicado: (2021)

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy
por: Hopfner, Franziska, et al.
Publicado: (2021)

Refractory Epstein-Barr Virus (EBV)-Related Post-transplant Lymphoproliferative Disease: Cure by Combined Brentuximab Vedotin and Allogeneic EBV-Specific T-Lymphocytes
por: Mika, Thomas, et al.
Publicado: (2019)

Patient-tailored adoptive immunotherapy with EBV-specific T cells from related and unrelated donors
por: Bonifacius, Agnes, et al.
Publicado: (2023)

Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering
por: Oberschmidt, Olaf, et al.
Publicado: (2019)

HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
por: Wachstein, Julian, et al.
Publicado: (2012)

Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
por: Grote-Levi, Lea, et al.
Publicado: (2023)

Advantages and applications of CAR-expressing natural killer cells
por: Glienke, Wolfgang, et al.
Publicado: (2015)

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation
por: Dragon, Anna Christina, et al.
Publicado: (2020)

Combined Treatment With Pembrolizumab and Allogenic BK Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy: A Case Report
por: Wicklein, Rebecca, et al.
Publicado: (2021)

Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy
por: Bonifacius, Agnes, et al.
Publicado: (2022)

Adoptive Cell Transfer of Allogeneic Epstein–Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report
por: Hansen, Bjoern-Thore, et al.
Publicado: (2021)

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications
por: Konen, Franz Felix, et al.
Publicado: (2022)

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2022)

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation
por: Sundarasetty, Bala Sai, et al.
Publicado: (2015)

CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
por: Dragon, Anna Christina, et al.
Publicado: (2023)

NKG2A silencing in effector cells to improve effectivity of cell based therapeutics
por: Figueiredo, C, et al.
Publicado: (2009)

Induced dendritic cells co-expressing GM-CSF/IFN-α/tWT1 priming T and B cells and automated manufacturing to boost GvL
por: Bialek-Waldmann, Julia K., et al.
Publicado: (2021)

Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality?
por: Gussarow, Daniel, et al.
Publicado: (2021)

Human calreticulin can act as adjuvant in the maturation of antigen presenting cells
por: Bajor, A, et al.
Publicado: (2009)

Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation
por: Mynarek, Martin, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_hnhbemhklmbcjm32sovmhg1ceg