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Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in signaling pathways. Recent work has demonstrated tha...

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Detalles Bibliográficos
Autores principales: Schaar, Claire E., Dues, Dylan J., Spielbauer, Katie K., Machiela, Emily, Cooper, Jason F., Senchuk, Megan, Hekimi, Siegfried, Van Raamsdonk, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335496/
https://www.ncbi.nlm.nih.gov/pubmed/25671321
http://dx.doi.org/10.1371/journal.pgen.1004972