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Combining Natural Sequence Variation with High Throughput Mutational Data to Reveal Protein Interaction Sites
Many protein interactions are conserved among organisms despite changes in the amino acid sequences that comprise their contact sites, a property that has been used to infer the location of these sites from protein homology. In an inter-species complementation experiment, a sequence present in a hom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335499/ https://www.ncbi.nlm.nih.gov/pubmed/25671604 http://dx.doi.org/10.1371/journal.pgen.1004918 |