Novel Inhibitors of Cholesterol Degradation in Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to support growth in macrophages. By conducting an extensive, unbiased chemical screen to identify small molecules that inhibit Mtb metabolism within macrophages, we identified a significant number of novel compounds...

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Detalles Bibliográficos
Autores principales: VanderVen, Brian C., Fahey, Ruth J., Lee, Wonsik, Liu, Yancheng, Abramovitch, Robert B., Memmott, Christine, Crowe, Adam M., Eltis, Lindsay D., Perola, Emanuele, Deininger, David D., Wang, Tiansheng, Locher, Christopher P., Russell, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335503/
https://www.ncbi.nlm.nih.gov/pubmed/25675247
http://dx.doi.org/10.1371/journal.ppat.1004679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335503/
https://www.ncbi.nlm.nih.gov/pubmed/25675247
http://dx.doi.org/10.1371/journal.ppat.1004679

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