Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth

Hypoxia-inducible factor-1 (HIF-1) is a master regulator of the transcriptional response to hypoxia. HIF-1α is one of the most compelling anticancer targets. Andrographolide (Andro) was newly identified to inhibit HIF-1 in T47D cells (a half maximal effective concentration [EC(50)] of 1.03×10(−7) mo...

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Detalles Bibliográficos
Autores principales: Li, Jie, Zhang, Chao, Jiang, Hongchuan, Cheng, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335622/
https://www.ncbi.nlm.nih.gov/pubmed/25709476
http://dx.doi.org/10.2147/OTT.S76116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335622/
https://www.ncbi.nlm.nih.gov/pubmed/25709476
http://dx.doi.org/10.2147/OTT.S76116

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