The role of the insulin-like growth factor-1 system in breast cancer

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a g...

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Autores principales: Christopoulos, Panagiotis F, Msaouel, Pavlos, Koutsilieris, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335664/
https://www.ncbi.nlm.nih.gov/pubmed/25743390
http://dx.doi.org/10.1186/s12943-015-0291-7
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author Christopoulos, Panagiotis F
Msaouel, Pavlos
Koutsilieris, Michael
author_facet Christopoulos, Panagiotis F
Msaouel, Pavlos
Koutsilieris, Michael
author_sort Christopoulos, Panagiotis F
collection PubMed
description IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.
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spelling pubmed-43356642015-02-21 The role of the insulin-like growth factor-1 system in breast cancer Christopoulos, Panagiotis F Msaouel, Pavlos Koutsilieris, Michael Mol Cancer Review IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies. BioMed Central 2015-02-15 /pmc/articles/PMC4335664/ /pubmed/25743390 http://dx.doi.org/10.1186/s12943-015-0291-7 Text en © Christopoulos et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Christopoulos, Panagiotis F
Msaouel, Pavlos
Koutsilieris, Michael
The role of the insulin-like growth factor-1 system in breast cancer
title The role of the insulin-like growth factor-1 system in breast cancer
title_full The role of the insulin-like growth factor-1 system in breast cancer
title_fullStr The role of the insulin-like growth factor-1 system in breast cancer
title_full_unstemmed The role of the insulin-like growth factor-1 system in breast cancer
title_short The role of the insulin-like growth factor-1 system in breast cancer
title_sort role of the insulin-like growth factor-1 system in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335664/
https://www.ncbi.nlm.nih.gov/pubmed/25743390
http://dx.doi.org/10.1186/s12943-015-0291-7
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