Promiscuous Binding of Karyopherinβ1 Modulates FG Nucleoporin Barrier Function and Expedites NTF2 Transport Kinetics

The transport channel of nuclear pore complexes (NPCs) contains a high density of intrinsically disordered proteins that are rich in phenylalanine-glycine (FG)-repeat motifs (FG Nups). The FG Nups interact promiscuously with various nuclear transport receptors (NTRs), such as karyopherins (Kaps), th...

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Detalles Bibliográficos
Autores principales: Wagner, Raphael S., Kapinos, Larisa E., Marshall, Neil J., Stewart, Murray, Lim, Roderick Y.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2015
Materias:
Proteins and Nucleic Acids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336380/
https://www.ncbi.nlm.nih.gov/pubmed/25692596
http://dx.doi.org/10.1016/j.bpj.2014.12.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336380/
https://www.ncbi.nlm.nih.gov/pubmed/25692596
http://dx.doi.org/10.1016/j.bpj.2014.12.041

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