A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

BACKGROUND: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. METHODS: To overcome this problem, we used a novel immunogen des...

Descripción completa

Detalles Bibliográficos
Autores principales: Mothe, Beatriz, Hu, Xintao, Llano, Anuska, Rosati, Margherita, Olvera, Alex, Kulkarni, Viraj, Valentin, Antonio, Alicea, Candido, Pilkington, Guy R, Sardesai, Niranjan Y, Rocafort, Muntsa, Crespo, Manel, Carrillo, Jorge, Marco, Andrés, Mullins, James I, Dorrell, Lucy, Hanke, Tomáš, Clotet, Bonaventura, Pavlakis, George N, Felber, Barbara K, Brander, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336696/
https://www.ncbi.nlm.nih.gov/pubmed/25879820
http://dx.doi.org/10.1186/s12967-015-0392-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336696/
https://www.ncbi.nlm.nih.gov/pubmed/25879820
http://dx.doi.org/10.1186/s12967-015-0392-5

Ejemplares similares