Evaluating the Use of Linear Mixed-Effect Models for Inference of the Concentration-QTc Slope Estimate as a Surrogate for a Biological QTc Model

In concentration-QTc modeling, oscillatory functions have been used to characterize biological rhythms in QTc profiles. Fitting such functions is not always feasible because it requires sufficient electrocardiograph sampling. In this study, drug concentration and QTc data were simulated using a publ...

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Detalles Bibliográficos
Autores principales: Huh, Y, Hutmacher, MM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337253/
https://www.ncbi.nlm.nih.gov/pubmed/26225224
http://dx.doi.org/10.1002/psp4.14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337253/
https://www.ncbi.nlm.nih.gov/pubmed/26225224
http://dx.doi.org/10.1002/psp4.14

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