Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation

Members of the Tolloid family of metalloproteinases liberate BMPs from inhibitory complexes to regulate BMP gradient formation during embryonic dorsal-ventral axis patterning. Here, we determine mechanistically how Tolloid activity is regulated by its non-catalytic CUB domains in the Drosophila embr...

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Detalles Bibliográficos
Autores principales: Winstanley, Jennifer, Sawala, Annick, Baldock, Clair, Ashe, Hilary L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337604/
https://www.ncbi.nlm.nih.gov/pubmed/25642644
http://dx.doi.org/10.7554/eLife.05508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337604/
https://www.ncbi.nlm.nih.gov/pubmed/25642644
http://dx.doi.org/10.7554/eLife.05508

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