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Activity and Ca(2+) regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons

TRPV1 channels are gated by a variety of thermal, chemical, and mechanical stimuli. We used optical recording of Ca(2+) influx through TRPV1 to measure activity and mobility of single TRPV1 molecules in isolated dorsal root ganglion neurons and cell lines. The opening of single TRPV1 channels produc...

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Detalles Bibliográficos
Autores principales: Senning, Eric N, Gordon, Sharona E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337616/
https://www.ncbi.nlm.nih.gov/pubmed/25569155
http://dx.doi.org/10.7554/eLife.03819