A kinase-independent function of AKT promotes cancer cell survival

The serine–threonine kinase AKT regulates proliferation and survival by phosphorylating a network of protein substrates. In this study, we describe a kinase-independent function of AKT. In cancer cells harboring gain-of-function alterations in MET, HER2, or Phosphatidyl-Inositol-3-Kinase (PI3K), cat...

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Detalles Bibliográficos
Autores principales: Vivanco, Igor, Chen, Zhi C, Tanos, Barbara, Oldrini, Barbara, Hsieh, Wan-Ying, Yannuzzi, Nicolas, Campos, Carl, Mellinghoff, Ingo K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337624/
https://www.ncbi.nlm.nih.gov/pubmed/25551293
http://dx.doi.org/10.7554/eLife.03751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337624/
https://www.ncbi.nlm.nih.gov/pubmed/25551293
http://dx.doi.org/10.7554/eLife.03751

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