Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein C(H)1 to initiate ER stress signaling

The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis. How cells detect the accumulation of misfolded proteins remains uncl...

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Detalles Bibliográficos
Autores principales: Carrara, Marta, Prischi, Filippo, Nowak, Piotr R, Kopp, Megan C, Ali, Maruf MU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337721/
https://www.ncbi.nlm.nih.gov/pubmed/25692299
http://dx.doi.org/10.7554/eLife.03522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337721/
https://www.ncbi.nlm.nih.gov/pubmed/25692299
http://dx.doi.org/10.7554/eLife.03522

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