The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are incompletely understood. Here we show that two related s...

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Detalles Bibliográficos
Autores principales: Wei, Yongjie, An, Zhenyi, Zou, Zhongju, Sumpter, Rhea, Su, Minfei, Zang, Xiao, Sinha, Sangita, Gaestel, Matthias, Levine, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337728/
https://www.ncbi.nlm.nih.gov/pubmed/25693418
http://dx.doi.org/10.7554/eLife.05289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337728/
https://www.ncbi.nlm.nih.gov/pubmed/25693418
http://dx.doi.org/10.7554/eLife.05289

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