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Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis

Break-induced replication (BIR) has been implicated in restoring eroded telomeres and collapsed replication forks via single-ended invasion and extensive DNA synthesis on the recipient chromosome. Unlike other recombination subtypes, DNA synthesis in BIR likely relies heavily on mechanisms enabling...

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Detalles Bibliográficos
Autores principales: Che, Jun, Smith, Stephanie, Kim, Yoo Jung, Shim, Eun Yong, Myung, Kyungjae, Lee, Sang Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338291/
https://www.ncbi.nlm.nih.gov/pubmed/25705897
http://dx.doi.org/10.1371/journal.pgen.1004990