Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

OBJECTIVE: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. METHODS: We utilize flux balance c...

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Detalles Bibliográficos
Autores principales: Nogiec, Christopher, Burkart, Alison, Dreyfuss, Jonathan M., Lerin, Carles, Kasif, Simon, Patti, Mary-Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338313/
https://www.ncbi.nlm.nih.gov/pubmed/25737951
http://dx.doi.org/10.1016/j.molmet.2014.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338313/
https://www.ncbi.nlm.nih.gov/pubmed/25737951
http://dx.doi.org/10.1016/j.molmet.2014.12.012

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