Cargando…

Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

OBJECTIVE: Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. METHODS: We utilize flux balance c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nogiec, Christopher, Burkart, Alison, Dreyfuss, Jonathan M., Lerin, Carles, Kasif, Simon, Patti, Mary-Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338313/ https://www.ncbi.nlm.nih.gov/pubmed/25737951 http://dx.doi.org/10.1016/j.molmet.2014.12.012

Ejemplares similares

To Supplement or Not to Supplement: A Metabolic Network Framework for Human Nutritional Supplements
por: Nogiec, Christopher D., et al.
Publicado: (2013)

Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism
por: Lerin, Carles, et al.
Publicado: (2016)

Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
por: Kim, Bhumsoo, et al.
Publicado: (2015)

Brain insulin receptors link stress and metabolism()
por: Woods, Stephen C., et al.
Publicado: (2014)

The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism
por: Wacławczyk, Dorota, et al.
Publicado: (2021)

Carotid body, insulin, and metabolic diseases: unraveling the links
por: Conde, Sílvia V., et al.
Publicado: (2014)

Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function
por: Burkart, Alison M., et al.
Publicado: (2016)

Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes
por: Shah, Ravi, et al.
Publicado: (2017)

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion
por: Gheni, Ghupurjan, et al.
Publicado: (2014)

Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice
por: Vitry, Geraldine, et al.
Publicado: (2022)

The Messy Alkaline Formose Reaction and Its Link to Metabolism
por: Omran, Arthur, et al.
Publicado: (2020)

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock()
por: Dyar, Kenneth A., et al.
Publicado: (2013)

Insulin Resistance and Muscle Metabolism in Chronic Kidney Disease
por: Bailey, James L.
Publicado: (2013)

Targeting the metabolic profile of amino acids to identify the key metabolic characteristics in cerebral palsy
por: Wang, Dan, et al.
Publicado: (2023)

Comparison of Muscle Transcriptome between Pigs with Divergent Meat Quality Phenotypes Identifies Genes Related to Muscle Metabolism and Structure
por: Damon, Marie, et al.
Publicado: (2012)

Totoro: Identifying Active Reactions During the Transient State for Metabolic Perturbations
por: Galvão Ferrarini, Mariana, et al.
Publicado: (2022)

A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease
por: Mori, Marcelo A., et al.
Publicado: (2010)

A metabolic link to skeletal muscle wasting and regeneration
por: Koopman, René, et al.
Publicado: (2014)

Linking muscle mechanics to the metabolic cost of human hopping
por: Jessup, Luke N., et al.
Publicado: (2023)

Muscle, inflammation and metabolic health: is irisin the missing link?
Publicado: (2017)

REPTOR and CREBRF encode key regulators of muscle energy metabolism
por: Saavedra, Pedro, et al.
Publicado: (2023)

Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells
por: Ramos Costa, Suzana Maria, et al.
Publicado: (2016)

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism
por: Li, Mengyao, et al.
Publicado: (2015)

Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle
por: Ding, Yi, et al.
Publicado: (2015)

Dynamic changes of muscle insulin sensitivity after metabolic surgery
por: Gancheva, Sofiya, et al.
Publicado: (2019)

Long term conservation of human metabolic phenotypes and link to heritability
por: Yousri, Noha A., et al.
Publicado: (2014)

Editorial: Metabolism Linking Immunity and Inflammatory Phenotypes in Cardiovascular Disease
por: Vijayan, Murali, et al.
Publicado: (2022)

Insulin sensitivity of muscle protein metabolism is altered in patients with chronic kidney disease and metabolic acidosis
por: Garibotto, Giacomo, et al.
Publicado: (2015)

Metabolically Unhealthy Phenotype: A Key Factor in Determining “Pediatric” Frailty
por: Calcaterra, Valeria, et al.
Publicado: (2021)

MISC-1/OGC Links Mitochondrial Metabolism, Apoptosis and Insulin Secretion
por: Gallo, Marco, et al.
Publicado: (2011)

The use of metabolic profiling to identify insulin resistance in veal calves
por: Pantophlet, Andre J., et al.
Publicado: (2017)

The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
por: Hwang, You-Cheol, et al.
Publicado: (2016)

Inhibitory Potential of Turbinaria ornata against Key Metabolic Enzymes Linked to Diabetes
por: Unnikrishnan, P. S., et al.
Publicado: (2014)

Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells
por: Iovino, Salvatore, et al.
Publicado: (2014)

Mechanisms Linking the Gut-Muscle Axis With Muscle Protein Metabolism and Anabolic Resistance: Implications for Older Adults at Risk of Sarcopenia
por: Prokopidis, Konstantinos, et al.
Publicado: (2021)

Is Acetylation a Metabolic Rheostat that Regulates Skeletal Muscle Insulin Action?
por: LaBarge, Samuel, et al.
Publicado: (2015)

Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome
por: Jahn, Linda A., et al.
Publicado: (2022)

Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus
por: Sobrevia, Luis, et al.
Publicado: (2016)

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
por: Stoeckel, Luke E., et al.
Publicado: (2016)

Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance
por: Lark, Daniel S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_m41ov9vjrbm126pijdglidosg2