Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs

Saccharomyces cerevisiae Msl5 orchestrates spliceosome assembly by binding the intron branchpoint sequence 5′-UACUAAC and, with its heterodimer partner protein Mud2, establishing cross intron-bridging interactions with the U1 snRNP at the 5′ splice site. Here we define the central Msl5 KH-QUA2 domai...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacewicz, Agata, Chico, Lidia, Smith, Paul, Schwer, Beate, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338336/
https://www.ncbi.nlm.nih.gov/pubmed/25587180
http://dx.doi.org/10.1261/rna.048942.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338336/
https://www.ncbi.nlm.nih.gov/pubmed/25587180
http://dx.doi.org/10.1261/rna.048942.114

Ejemplares similares