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Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs

Saccharomyces cerevisiae Msl5 orchestrates spliceosome assembly by binding the intron branchpoint sequence 5′-UACUAAC and, with its heterodimer partner protein Mud2, establishing cross intron-bridging interactions with the U1 snRNP at the 5′ splice site. Here we define the central Msl5 KH-QUA2 domai...

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Detalles Bibliográficos
Autores principales:	Jacewicz, Agata, Chico, Lidia, Smith, Paul, Schwer, Beate, Shuman, Stewart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338336/ https://www.ncbi.nlm.nih.gov/pubmed/25587180 http://dx.doi.org/10.1261/rna.048942.114

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