Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels

Glutamate is an indispensable neurotransmitter, triggering postsynaptic signals upon recognition by postsynaptic receptors. We questioned the phylogenetic position and the molecular details of when and where glutamate recognition arose in the glutamate-gated chloride channels. Experiments revealed t...

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Detalles Bibliográficos
Autores principales: Lynagh, Timothy, Beech, Robin N., Lalande, Maryline J., Keller, Kevin, Cromer, Brett A., Wolstenholme, Adrian J., Laube, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338433/
https://www.ncbi.nlm.nih.gov/pubmed/25708000
http://dx.doi.org/10.1038/srep08558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338433/
https://www.ncbi.nlm.nih.gov/pubmed/25708000
http://dx.doi.org/10.1038/srep08558

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