Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis

BACKGROUND & AIMS: Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects. LL-37 also suppresses collagen synthesis, an important fibrotic response, in dermal fibroblasts. Here, we determined whether exogenous cath...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoo, Jun Hwan, Ho, Samantha, Tran, Deanna Hoang-Yen, Cheng, Michelle, Bakirtzi, Kyriaki, Kubota, Yuzu, Ichikawa, Ryan, Su, Bowei, Tran, Diana Hoang-Ngoc, Hing, Tressia C., Chang, Irene, Shih, David Q., Issacson, Richard E., Gallo, Richard L., Fiocchi, Claudio, Pothoulakis, Charalabos, Koon, Hon Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338438/
https://www.ncbi.nlm.nih.gov/pubmed/25729764
http://dx.doi.org/10.1016/j.jcmgh.2014.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338438/
https://www.ncbi.nlm.nih.gov/pubmed/25729764
http://dx.doi.org/10.1016/j.jcmgh.2014.08.001

Ejemplares similares