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Charge-driven dynamics of nascent chain movement through the SecYEG translocon

On average, every fifth residue in secretory proteins carries either a positive or a negative charge. In a bacterium such as Escherichia coli, charged residues are exposed to an electric field as they transit through the inner membrane, which should generate a fluctuating electric force on a translo...

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Detalles Bibliográficos
Autores principales: Ismail, Nurzian, Hedman, Rickard, Lindén, Martin, von Heijne, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338579/
https://www.ncbi.nlm.nih.gov/pubmed/25558985
http://dx.doi.org/10.1038/nsmb.2940