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Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy

INTRODUCTION: Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β-cyclodextrin (SBECD). The purpose of this study was to evaluate the pharmacokinetics of SBECD, voriconazole, and voriconazol...

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Detalles Bibliográficos
Autores principales:	Kiser, Tyree H, Fish, Douglas N, Aquilante, Christina L, Rower, Joseph E, Wempe, Michael F, MacLaren, Robert, Teitelbaum, Isaac
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338618/ https://www.ncbi.nlm.nih.gov/pubmed/25645660 http://dx.doi.org/10.1186/s13054-015-0753-8

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