Cargando…

Anti‐Inflammatory Immune Skewing Is Atheroprotective: Apoe(−/−)FcγRIIb(−/−) Mice Develop Fibrous Carotid Plaques

BACKGROUND: Stroke, caused by carotid plaque rupture, is a major cause of death in the United States. Whereas vulnerable human plaques have higher Fc receptor (FcγR) expression than their stable counterparts, how FcγR expression impacts plaque histology is unknown. We investigated the role of FcγRII...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harmon, Erin Y., Fronhofer, Van, Keller, Rebecca S., Feustel, Paul J., Zhu, Xinmei, Xu, Hao, Avram, Dorina, Jones, David M., Nagarajan, Shanmugam, Lennartz, Michelle R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338708/ https://www.ncbi.nlm.nih.gov/pubmed/25516435 http://dx.doi.org/10.1161/JAHA.114.001232

Ejemplares similares

Ultrasound Biomicroscopy for Longitudinal Studies of Carotid Plaque Development in Mice: Validation with Histological Endpoints
por: Harmon, Erin Y., et al.
Publicado: (2012)

Ligation of Macrophage Fcγ Receptors Recapitulates the Gene Expression Pattern of Vulnerable Human Carotid Plaques
por: Lennartz, Michelle R., et al.
Publicado: (2011)

Regulation of Monoclonal Antibody Immunotherapy by FcγRIIB
por: Stopforth, Richard J., et al.
Publicado: (2016)

The Complex Association of FcγRIIb With Autoimmune Susceptibility
por: Verbeek, J. Sjef, et al.
Publicado: (2019)

Transmembrane domain dependent inhibitory function of FcγRIIB
por: Wang, Junyi, et al.
Publicado: (2018)

FcγRIIB is a T cell checkpoint in antitumor immunity
por: Farley, Clara R., et al.
Publicado: (2021)

Role of lipid nanodomains for inhibitory FcγRIIb function
por: Spiegel, Franziska, et al.
Publicado: (2023)

Distinct cell-specific control of autoimmunity and infection by FcγRIIb
por: Brownlie, Rebecca J., et al.
Publicado: (2008)

Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB(−/−) Mice
por: Bolland, Silvia, et al.
Publicado: (2002)

High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis
por: Magnusson, Sofia E, et al.
Publicado: (2007)

Lupus-like Disease in FcγRIIB(−/−) Mice Induces Osteopenia
por: Visitchanakun, Peerapat, et al.
Publicado: (2019)

Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100
por: Tse, Kevin, et al.
Publicado: (2013)

IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells
por: Gast, Mathias, et al.
Publicado: (2018)

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein
por: Papaioannou, Ioannis, et al.
Publicado: (2012)

Functional Role of FcγRIIB in the Regulation of Mesenchymal Stem Cell Function
por: Zhu, Tianyi, et al.
Publicado: (2016)

Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy–Focus on FcγRIIB
por: Teige, Ingrid, et al.
Publicado: (2019)

Identification of candidate regulators of mandibular bone loss in FcγRIIB(-/-) Mice
por: Sakunrangsit, Nithidol, et al.
Publicado: (2021)

Recombinant Factor VIII Fc Inhibits B Cell Activation via Engagement of the FcγRIIB Receptor
por: Georgescu, Maria T., et al.
Publicado: (2020)

B Lymphocyte Memory: Role of Stromal Cell Complement and FcγRIIB Receptors
por: Barrington, Robert A., et al.
Publicado: (2002)

FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis
por: Clatworthy, Menna R., et al.
Publicado: (2004)

Dexamethasone Induces FcγRIIb Expression in RBL-2H3 Cells
por: Silwal, Prashanta, et al.
Publicado: (2012)

FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding
por: Hu, Wei, et al.
Publicado: (2019)

FcγRIIb blockage: a promising immunotherapy target for severe COVID-19
por: He, Xuemei, et al.
Publicado: (2021)

Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index
por: Karimifar, Mansoor, et al.
Publicado: (2021)

Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis
por: Kanari, Yasuyoshi, et al.
Publicado: (2014)

Correction to: Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index
por: Karimifar, Mansoor, et al.
Publicado: (2022)

FcγRIIb Inhibits Allergic Lung Inflammation in a Murine Model of Allergic Asthma
por: Dharajiya, Nilesh, et al.
Publicado: (2010)

A general requirement for FcγRIIB co-engagement of agonistic anti-TNFR antibodies
por: Li, Fubin, et al.
Publicado: (2012)

FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape
por: Wu, Lei, et al.
Publicado: (2022)

FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation
por: Barlev, Ashley N., et al.
Publicado: (2022)

Antibody-Targeted TNFRSF Activation for Cancer Immunotherapy: The Role of FcγRIIB Cross-Linking
por: Liu, Luyan, et al.
Publicado: (2022)

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms
por: Simpson, Alexander P., et al.
Publicado: (2022)

Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131)
por: Mimoto, F., et al.
Publicado: (2013)

LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice
por: Hong, Cynthia, et al.
Publicado: (2012)

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling
por: Patin, Emmanuel C., et al.
Publicado: (2017)

Vector induced skewing of antibody Fc-effector functions
por: Chung, A, et al.
Publicado: (2012)

Porcine FcγRIIb Mediates Enhancement of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
por: Qiao, Songlin, et al.
Publicado: (2011)

Therapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia
por: Parting, Oliver, et al.
Publicado: (2020)

IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
por: Liu, Yunmian, et al.
Publicado: (2019)

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB
por: van der Poel, Cees E., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n0bqgo3rq9abj6mmv74ps1nori