Mouse ERG K(+) Channel Clones Reveal Differences in Protein Trafficking and Function

BACKGROUND: The mouse ether‐a‐go‐go‐related gene 1a (mERG1a, mKCNH2) encodes mERG K(+) channels in mouse cardiomyocytes. The mERG channels and their human analogue, hERG channels, conduct I(Kr). Mutations in hERG channels reduce I(Kr) to cause congenital long‐QT syndrome type 2, mostly by decreasing...

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Detalles Bibliográficos
Autores principales: Lin, Eric C., Moungey, Brooke M., Lim, Evi, Concannon, Sarah P., Anderson, Corey L., Kyle, John W., Makielski, Jonathan C., Balijepalli, Sadguna Y., January, Craig T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338741/
https://www.ncbi.nlm.nih.gov/pubmed/25497881
http://dx.doi.org/10.1161/JAHA.114.001491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338741/
https://www.ncbi.nlm.nih.gov/pubmed/25497881
http://dx.doi.org/10.1161/JAHA.114.001491

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