Cargando…

Design, synthesis, and computational studies on dihydropyrimidine scaffolds as potential lipoxygenase inhibitors and cancer chemopreventive agents

Dihydropyrimidine scaffold has a wide range of potential pharmacological activities such as antiviral, antitubercular, antimalarial, anti-inflammatory, and anticancer properties. 5-Lipoxygenase enzyme is an enzyme responsible for the metabolism of arachidonic acid to leukotrienes. The elevated level...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venugopala, Katharigatta N, Govender, Reshme, Khedr, Mohammed A, Venugopala, Rashmi, Aldhubiab, Bandar E, Harsha, Sree, Odhav, Bharti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338777/ https://www.ncbi.nlm.nih.gov/pubmed/25733811 http://dx.doi.org/10.2147/DDDT.S73890

Ejemplares similares

Design, Synthesis, and In Vitro Evaluation of Novel Indolyl DiHydropyrazole Derivatives as Potential Anticancer Agents
por: Venugopala, Katharigatta N., et al.
Publicado: (2021)

2-(4-Bromoanilino)-6-(4-chlorophenyl)-5-methoxycarbonyl-4-methyl-3,6-dihydropyrimidin-1-ium chloride
por: Venugopala, K. N., et al.
Publicado: (2013)

Evaluation of Halogenated Coumarins for Antimosquito Properties
por: Narayanaswamy, Venugopala K., et al.
Publicado: (2014)

Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
por: Venugopala, Katharigatta N, et al.
Publicado: (2020)

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues
por: Venugopala, Katharigatta Narayanaswamy, et al.
Publicado: (2019)

Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification
por: Venugopala, Katharigatta N., et al.
Publicado: (2019)

Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis
por: Venugopala, Katharigatta N, et al.
Publicado: (2016)

Correction: Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
por: Attimarad, Mahesh, et al.
Publicado: (2019)

Crystal structure of methyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate
por: Bairagi, Keshab M., et al.
Publicado: (2016)

Immobilization studies of Candida Antarctica lipase B on gallic acid resin-grafted magnetic iron oxide nanoparticles
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity
por: Venugopala, K. N., et al.
Publicado: (2013)

Methyl 2,6-diphenyl-1-p-tolyl-4-(p-tolylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate
por: Venugopala, K. N., et al.
Publicado: (2012)

Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-carboxylate
por: Nayak, Susanta K., et al.
Publicado: (2012)

Methyl (E)-2-[(3-chloro-4-cyanophenyl)imino]-4-(4-chlorophenyl)-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
por: Venugopala, K. N., et al.
Publicado: (2012)

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion
por: Harsha, Sree N, et al.
Publicado: (2015)

Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole
por: Nair, Anroop B., et al.
Publicado: (2023)

Targeting the DNA Damage Response Machinery for Lung Cancer Treatment
por: Venugopala, Katharigatta N.
Publicado: (2022)

An Approach to Enhance Dissolution Rate of Tamoxifen Citrate
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Graphene-based hybrid nanoparticle of doxorubicin for cancer chemotherapy
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Mucoadhesive Particles: A Novel, Prolonged-Release Nanocarrier of Sitagliptin for the Treatment of Diabetics
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System Derived Tablet Containing Sertraline
por: Nair, Anroop B., et al.
Publicado: (2022)

Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies
por: Nair, Anroop B., et al.
Publicado: (2022)

{2-[(1,3-Benzothiazol-2-yl)methoxy]-5-chlorophenyl}(4-chlorophenyl)methanone
por: Venugopala, K. N., et al.
Publicado: (2013)

{2-[(1,3-Benzothiazol-2-yl)methoxy]-5-bromophenyl}(phenyl)methanone
por: Venugopala, K. N., et al.
Publicado: (2013)

Microwave Assisted Synthesis, Pharmacological Activities, and Molecular Docking Studies of Ethyl 2-[2-Substituted-4-(Thiophenyl) Thiazolyl] Acetates
por: Attimarad, Mahesh Veerabhadra, et al.
Publicado: (2017)

Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection
por: Alwassil, Osama I., et al.
Publicado: (2019)

2-[(1R,3S)-6,7-Dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-phenyl-1,3-thiazole
por: Pawar, Sunayna, et al.
Publicado: (2011)

Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch
por: Nair, Anroop B., et al.
Publicado: (2019)

Computational Design, Synthesis, and Pharmacological Evaluation of Naproxen-Guaiacol Chimera for Gastro-Sparing Anti-Inflammatory Response by Selective COX2 Inhibition
por: Shinu, Pottathil, et al.
Publicado: (2022)

Development of Ecofriendly Derivative Spectrophotometric Methods for the Simultaneous Quantitative Analysis of Remogliflozin and Vildagliptin from Formulation
por: Attimarad, Mahesh, et al.
Publicado: (2021)

An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
por: SreeHarsha, Nagaraja, et al.
Publicado: (2019)

Crystallography, in Silico Studies, and In Vitro Antifungal Studies of 2,4,5 Trisubstituted 1,2,3-Triazole Analogues
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Development and Validation of Green UV Derivative Spectrophotometric Methods for Simultaneous Determination Metformin and Remogliflozin from Formulation: Evaluation of Greenness
por: Attimarad, Mahesh, et al.
Publicado: (2021)

Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies
por: Venugopala, Katharigatta N., et al.
Publicado: (2020)

Crystal structure analysis of [5-(4-methoxyphenyl)-2-methyl-2H-1,2,3-triazol-4-yl](thiophen-2-yl)methanone
por: Bhandary, Subhrajyoti, et al.
Publicado: (2018)

Antiglycation, comparative antioxidant potential, phenolic content and yield variation of essential oils from 19 exotic and endemic medicinal plants
por: Mahomoodally, F., et al.
Publicado: (2019)

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions
por: Sánchez-Sancho, Francisco, et al.
Publicado: (2022)

Screening and Molecular Docking of Novel Benzothiazole Derivatives as Potential Antimicrobial Agents
por: Morsy, Mohamed A., et al.
Publicado: (2020)

Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation
por: Gounaris, Elias, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_232u8bifb4c1vutvipf6kptjf6