BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

Loss of telomere protection occurs during physiological cell senescence and ageing, due to attrition of telomeric repeats and insufficient retention of the telomere-binding factor TRF2. Subsequently formed telomere fusions trigger rampant genomic instability leading to cell death or tumorigenesis. M...

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Detalles Bibliográficos
Autores principales: Badie, Sophie, Carlos, Ana Rita, Folio, Cecilia, Okamoto, Keiji, Bouwman, Peter, Jonkers, Jos, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339125/
https://www.ncbi.nlm.nih.gov/pubmed/25582120
http://dx.doi.org/10.15252/embj.201488947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339125/
https://www.ncbi.nlm.nih.gov/pubmed/25582120
http://dx.doi.org/10.15252/embj.201488947

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