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The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy

Treatments for neuropathic pain are either not fully effective or have problematic side effects. Combinations of drugs are often used. Tapentadol is a newer molecule that produces analgesia in various pain models through two inhibitory mechanisms, namely central μ-opioid receptor (MOR) agonism and n...

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Detalles Bibliográficos
Autores principales: Gonçalves, Leonor, Friend, Lauren V., Dickenson, Anthony H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339205/
https://www.ncbi.nlm.nih.gov/pubmed/25576174
http://dx.doi.org/10.1016/j.ejphar.2014.11.032