Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation

Signal transducers and activators of transcription (STATs) facilitate action of cytokines, growth factors and pathogens. STAT activation is mediated by a highly conserved SH2 domain, which interacts with phosphotyrosine motifs for specific STAT-receptor contacts and STAT dimerization. The active dim...

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Detalles Bibliográficos
Autores principales: Szelag, Malgorzata, Czerwoniec, Anna, Wesoly, Joanna, Bluyssen, Hans A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339377/
https://www.ncbi.nlm.nih.gov/pubmed/25710482
http://dx.doi.org/10.1371/journal.pone.0116688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339377/
https://www.ncbi.nlm.nih.gov/pubmed/25710482
http://dx.doi.org/10.1371/journal.pone.0116688

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