Cargando…

Identification of STAT1 and STAT3 Specific Inhibitors Using Comparative Virtual Screening and Docking Validation

Signal transducers and activators of transcription (STATs) facilitate action of cytokines, growth factors and pathogens. STAT activation is mediated by a highly conserved SH2 domain, which interacts with phosphotyrosine motifs for specific STAT-receptor contacts and STAT dimerization. The active dim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Szelag, Malgorzata, Czerwoniec, Anna, Wesoly, Joanna, Bluyssen, Hans A. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339377/ https://www.ncbi.nlm.nih.gov/pubmed/25710482 http://dx.doi.org/10.1371/journal.pone.0116688

Ejemplares similares

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
por: Szelag, Malgorzata, et al.
Publicado: (2016)

SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
por: Plens-Gałąska, Martyna, et al.
Publicado: (2022)

Data Mining of Atherosclerotic Plaque Transcriptomes Predicts STAT1-Dependent Inflammatory Signal Integration in Vascular Disease
por: Sikorski, Krzysztof, et al.
Publicado: (2014)

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs
por: Plens-Galaska, Martyna, et al.
Publicado: (2018)

STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction
por: Sikorski, Krzysztof, et al.
Publicado: (2012)

STAT2-directed pathogen responses
por: Bluyssen, Hans
Publicado: (2015)

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
por: Blaszczyk, Katarzyna, et al.
Publicado: (2015)

Identification of novel STAT3 inhibitors for liver fibrosis, using pharmacophore-based virtual screening, molecular docking, and biomolecular dynamics simulations
por: Rafiq, Huma, et al.
Publicado: (2023)

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy
por: Eskandarian Boroujeni, Mahdi, et al.
Publicado: (2022)

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription
por: Piaszyk-Borychowska, Anna, et al.
Publicado: (2019)

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
por: Liu, L-J, et al.
Publicado: (2014)

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis
por: Chmielewski, Stefan, et al.
Publicado: (2014)

The epigenetic landscape of clear-cell renal cell carcinoma
por: Kluzek, Katarzyna, et al.
Publicado: (2015)

Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets
por: Lee, Chien-Kuo, et al.
Publicado: (2019)

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors
por: Wrzesiński, Tomasz, et al.
Publicado: (2015)

Potential Approaches and Recent Advances in Biomarker Discovery in Clear-Cell Renal Cell Carcinoma
por: Majer, Weronika, et al.
Publicado: (2015)

Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates
por: Pstrąg, Natalia, et al.
Publicado: (2018)

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors
por: Granchi, Carlotta, et al.
Publicado: (2015)

Identification of RCC Subtype-Specific microRNAs–Meta-Analysis of High-Throughput RCC Tumor microRNA Expression Data
por: Kajdasz, Arkadiusz, et al.
Publicado: (2021)

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses
por: Michalska, Agata, et al.
Publicado: (2018)

Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations
por: Park, Hwangseo, et al.
Publicado: (2013)

Virtual screening of RAGE inhibitors using molecular docking
por: Devi Alaparthi, Malini, et al.
Publicado: (2016)

Discovery of potent STAT3 inhibitors using structure-based virtual screening, molecular dynamic simulation, and biological evaluation
por: Liu, Weifeng, et al.
Publicado: (2023)

Identification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay
por: Jang, Cheongyun, et al.
Publicado: (2018)

Stafia‐1: a STAT5a‐Selective Inhibitor Developed via Docking‐Based Screening of in Silico O‐Phosphorylated Fragments
por: Natarajan, Kalaiselvi, et al.
Publicado: (2019)

Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation
por: Niu, Guo-Juan, et al.
Publicado: (2018)

Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
por: Hua, Yaping, et al.
Publicado: (2022)

STAT inhibitors for cancer therapy
por: Furqan, Muhammad, et al.
Publicado: (2013)

Comparative Assessment of Docking Programs for Docking and Virtual Screening of Ribosomal Oxazolidinone Antibacterial Agents
por: Buckley, McKenna E., et al.
Publicado: (2023)

FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data
por: Zodro, Elżbieta, et al.
Publicado: (2013)

Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking
por: Elseginy, Samia A., et al.
Publicado: (2022)

Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets
por: Walker, Sarah R., et al.
Publicado: (2012)

Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
por: Zhang, Yi, et al.
Publicado: (2020)

Identification of JAK/STAT pathway regulators—Insights from RNAi screens
por: Müller, Patrick, et al.
Publicado: (2008)

Docking and virtual screening of novel inhibitors for mono-ADP-ribosylating toxins
por: Scharfe, M, et al.
Publicado: (2011)

Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
por: Ozbuyukkaya, Gizem, et al.
Publicado: (2013)

The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening
por: Kim, Jun-Tae, et al.
Publicado: (2014)

WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors
por: Scarpino, Andrea, et al.
Publicado: (2021)

Overview of the STAT-3 signaling pathway in cancer and the development of specific inhibitors
por: Gu, Yuchen, et al.
Publicado: (2020)

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease
por: Antonczyk, Aleksandra, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9hhsehboc8f6b9ojplrtlvtnta