Salubrinal Acts as a Dusp2 Inhibitor and Suppresses Inflammation in Anti-Collagen Antibody-Induced Arthritis

Dual-specificity phosphatase 2 (Dusp2; also called phosphatase of activated cells 1, PAC1) is highly expressed in activated immune cells. We examined whether a potential inhibitor of Dusp2, salubrinal, prevents inflammatory cytokine expression in immune cells and arthritic responses in a mouse model...

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Detalles Bibliográficos
Autores principales: Hamamura, Kazunori, Nishimura, Akinobu, Chen, Andy, Takigawa, Shinya, Sudo, Akihiro, Yokota, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339503/
https://www.ncbi.nlm.nih.gov/pubmed/25619567
http://dx.doi.org/10.1016/j.cellsig.2015.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339503/
https://www.ncbi.nlm.nih.gov/pubmed/25619567
http://dx.doi.org/10.1016/j.cellsig.2015.01.010

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